Increased γ-glutamyl transferase is commonly associated with hepatocellular injury or capillary bile duct epithelial cell injury, mostly due to alcoholic drug-related hepatitis, viral hepatitis, and biliary obstructive disease. It is recommended to visit the hospital in time to determine the cause and treat the cause. Common causes and treatments a, alcoholic, drug hepatitis: If the results of liver function is only elevated glutamyl transferase, may be due to long-term alcohol consumption caused by alcoholic hepatitis, or taking certain liver-damaging drugs caused by drug hepatitis, timely cessation of alcohol, discontinuation of drugs, glutamyl transferase will decline, may recover on its own, no special treatment, regular review can be. If the patient’s condition is more serious, jaundice, abdominal distension, diarrhea, itchy skin and other manifestations, hospitalization is required. Second, viral hepatitis: In patients who develop viral hepatitis due to infection with different types of hepatitis viruses, blood tests may reveal elevated bilirubin levels, decreased serum albumin and elevated globulin levels in addition to increased γ-glutamyl transferase. The four common types are hepatitis A, hepatitis B, hepatitis C and hepatitis E. The treatment methods for the four types are different: 1. Hepatitis A: antiviral therapy is generally not required, and appropriate liver-protective drugs can be applied according to medical advice, such as liver protection tablets and compound glycopyrrolate injection; 2. Hepatitis B: patients with hepatitis B first need antiviral therapy with drugs such as lamivudine, entecavir and telbivudine, and for patients with antiviral indications generally For relatively young people (including adolescent patients), those who wish to have children in recent years, those who expect to complete treatment in the short term, and those who are receiving antiviral therapy for the first time, interferon therapy can be given; 3, hepatitis C: antiviral therapy with drugs such as sofosbuvir and gekarevir, and regular follow-up, when the RNA of hepatitis C virus in the blood is not detected, the treatment can be considered successful; 4, hepatitis E: antiviral therapy is generally not given. Hepatoprotective therapy can be given symptomatically, such as vitamins, glucuronolactone and other non-specific hepatoprotective drugs. Biliary tract obstructive diseases: such as gallbladder stones, biliary tract obstruction and other diseases can induce hepatocytes to produce a large amount of γ-glutamyl transferase, which can even reach more than ten times the reference value in severe cases. Patients are advised to seek medical attention in time, perform abdominal CT examination, and after the diagnosis of biliary obstruction, surgery is usually required.