Pleurisy pain, located in the lower chest and lateral chest wall, is obvious and intensifies when the patient coughs and inhales deeply, mainly due to the intercostal neuralgia caused by the friction between the dirty pleura and the wall pleura during deep inspiration, which is a pinprick-like pain that can be felt as a frictional sensation in the chest. Sometimes the pain is very severe, and it is important to give appropriate pain medication to relieve the patient’s pain, such as indomethacin and intravenous drugs. If it is tuberculous pleurisy, regular anti-tuberculosis treatment should be given. In case of infectious pleurisy caused by common infection, cephalosporin and levofloxacin are also given. Etiological treatment is the most crucial, and the application of pain-relieving drugs alone is imperfect.