Hidden pain in the left upper abdomen may be related to cardiovascular system diseases and digestive system diseases. Patients should choose different drugs according to different causes to treat the cause. 1. Cardiovascular diseases: for example, common myocardial infarction, coronary heart disease and angina, etc., will stimulate the phrenic nerve leading to the patient’s left epigastric pain. Generally need to take anti-platelet aggregation drugs, such as aspirin, etc.; lipid-lowering drugs, such as simvastatin, etc.; antihypertensive drugs, such as captopril, nifedipine and so on. 2. Digestive system diseases: (1) Early pancreatitis: patients in the early stage of pancreatitis will have symptoms such as vague pain in the left upper abdomen, patients can use growth inhibitors to inhibit the secretion of pancreatic fluid and control the inflammatory response. (2) Gastritis: patients with gastritis may also experience discomfort in the left upper abdomen, and patients can use acid-suppressing drugs such as omeprazole and famotidine for treatment. (3) Colitis: Inflammation in the transverse colon area may also be manifested as vague pain in the left upper abdomen, and patients may be treated with aminosalicylic acid preparations such as mesalazine and salicylazosulfapyrimidine. It is recommended that patients go to the local hospital as soon as possible, to clarify the cause of the disease, under the guidance of the doctor to choose the appropriate drug treatment.