Renal colic is a common urological emergency, and the pain is often severe and unbearable during an attack. For most patients with renal colic, the pain can usually be relieved after treatment with antispasmodic and analgesic drugs. However, for women in pregnancy, the treatment of renal colic involves the fetus, and the main purpose of treatment is to prevent renal colic from inducing uterine contractions leading to miscarriage and preterm delivery, and to prevent the adverse effects of drugs from causing damage to mother and child, so we should be more careful with medication. So which drugs are safe and optional for patients with renal colic during pregnancy? Which drugs should be used as little as possible? The following will explain the safety of the commonly used antispasmodic and analgesic drugs used in clinical practice. 1, anti-inflammatory pain suppository: this product is a non-steroidal anti-inflammatory analgesic, with the role of inhibiting prostaglandin synthesis, its anti-inflammatory analgesic and antipyretic effects are related to the inhibition of prostaglandin synthesis. But because blocking prostaglandin synthesis can lead to premature closure of the fetal artery duct, so pregnant women should avoid using it. 2, progesterone: because progesterone has relaxation, expansion of the urinary smooth muscle, reduce the excitability of smooth muscle, has the effect of inhibiting pain. Therefore, it is often used as the first-line drug to relieve renal colic. However, it has been reported that the risk of malformation of fetal spine, anus and limbs can be increased 8 times by using a large amount of progesterone in early pregnancy. Therefore, for pregnant women, especially in early pregnancy, it is recommended to minimize its use. 3, 654-2, atropine: 654-2 and atropine belong to the same anticholinergic class, their main pharmacological effect is to release the spasm of smooth muscle and microvascular, and have analgesic effect. The antispasmodic effect of atropine on ureter is weak, and intravenous injection of atropine in pregnant women can cause fetal tachycardia. And 654-2 toxicity is small, so for patients with renal colic during pregnancy, 654-2 than atropine more commonly used. 4, magnesium sulfate: magnesium sulfate can cause vasodilation, resulting in a drop in blood pressure, and thus can treat hypertension during pregnancy. Magnesium ion acts directly on the smooth muscle cells of the uterus, antagonizing the effect of calcium ion on the uterine muscle contraction, inhibiting uterine contraction, so it can be used in the treatment of preterm abortion. For patients with renal colic in pregnancy, can be injected intravenously magnesium sulfate to achieve the role of antispasmodic, analgesic, but need to control the drip rate, pay attention to the lowering of blood pressure, to avoid hypotensive reactions. 5, morphine: for opioid receptor agonist. Its role through the simulation of endogenous antinociceptive substances enkephalin, agonize the central nervous opioid receptors and produce a strong analgesic effect. It is effective for all kinds of pain. However, because the drug can cross the placental barrier and affect the fetus, it can cause fetal drug dependence and withdrawal symptoms in newborns immediately after birth. Therefore, it is contraindicated to be used for pregnant and lactating women. 6, the choice of antibiotics: the use of antibiotics, try to use drugs that have little effect on the fetus. The effects of drugs on pregnant women are divided into five categories A, B, C, D, X. Category A is a drug that has been proven to have little effect on the fetus; category B is a drug that has not been proven to have an effect on the fetus; category C is a drug that has been proven in animal tests to have teratogenic and stillbirth side effects on the fetus and must be used after weighing the pros and cons; category D is a drug that has clear evidence of harm to the fetus; category X is a drug that is prohibited in pregnancy. In the classification of antibiotics penicillin is A, most cephalosporins are B, which are safe to use; quinolones and sulfonamides are C and above, so try to avoid using them. Therefore, for patients with renal colic during pregnancy, it is necessary to consider the safety of the pregnant woman and the fetus to reasonably choose the drugs, and it is recommended to go to a regular hospital and use the drugs under the guidance of a doctor to minimize the adverse effects of the drugs.