The skull plays a very important role in the health of the whole organism, it supports and protects the human head and face, it is an important guarantee to maintain the intracranial pressure and the intracranial environment, and even people figuratively compare the skull to the umbrella of the brain. However, when the hard skull is severely impacted by external forces, it can easily lead to the occurrence of cranial defects, and the patient will have to face problems in various aspects next. From the aesthetic point of view, skull defects lead to a great loss of face value, and if the defect area is large, the scalp will have obvious depression collapse, it will look more scary, the patient will be low self-esteem; and from the safety point of view, after the skull defects in the intracranial tissues of the shell of the lack of protection, directly by the outside world, if accidentally bumped into the risk of threats, it is a threat to life safety. Cranial defects also cause changes in the intracranial environment, intracranial pressure is unstable, cerebrospinal fluid circulation and blood circulation is affected, which affects the function of the brain and nerves, resulting in a series of uncomfortable symptoms, which is commonly referred to as craniosynostosis syndrome. What are the manifestations and contraindications of craniosynostosis syndrome? The main manifestations of craniosynostosis may include dizziness, headache, emotional instability, easily irritated, loss of limb muscle strength, fear of cold, fear of vibration, and lack of mental concentration, and so on. The impact of cranial defects is very big, so patients should pay attention to the importance of timely hospital cranial repair surgery. However, there are some contraindications to cranial bone repair surgery, such as the patient’s trauma site has an infected condition, there is obvious intracranial hypertension phenomenon, serious defects in the body organs, and even the performance of mental disorders, etc., these are not suitable for cranial bone repair surgery.