Highly differentiated squamous cell carcinoma is generally not as serious as undifferentiated and low-differentiated squamous cell carcinoma, and it also depends on the staging. Highly differentiated squamous cell carcinoma is classified according to the cell differentiation. Highly differentiated squamous cell carcinoma indicates that the morphology of cancer cells and normal cells are closer to each other, so the degree of malignancy is lower than that of poorly differentiated squamous cell carcinoma, and the overall prognosis is still good. However, it also needs to depend on the stage. In early stage, when there is no metastasis and spread of high differentiated squamous cell carcinoma and the cancer cells are still limited, the prognosis is relatively good if radical surgical resection is carried out in time; however, in advanced stage, high differentiated squamous cell carcinoma has already metastasized to lymphatic and distal organs, and the prognosis is poor, and it needs to be combined with radiotherapy and chemotherapy. Therefore, the severity of squamous cell carcinoma is not only related to the degree of differentiation, but also needs to be combined with the specific clinical stage. It is suggested that patients should go to regular hospitals to receive standardized treatment as early as possible to avoid delaying their condition.