Feeling itchy but do not know where itchy consider pruritus is more likely, mainly due to the following reasons: the first reason is the elderly sebaceous gland function is reduced, sebum secretion is reduced, the skin barrier function is weakened, in the skin surface can form a small break, leading to the occurrence of pruritus. The second may be due to the reduction of sebum caused by excessive rubbing of the skin, which causes the reduction of the skin barrier function. The third is due to internal disease factors, may be due to kidney failure or heart failure or serious coronary heart disease, diabetes, etc. caused by pruritus. Then the clinical treatment can be oral levocetirizine hydrochloride capsules, combined with loratadine citrate capsules, and topical application of furnace glycolic lotion to treat.