At the age of 65, kidney replacement is still necessary if it is needed and available. Kidney replacement is due to the loss of function of the original kidneys, i.e. severe renal failure or uremia, when the kidneys have no function for the human body and are not able to expel the excretions from the body, and these toxins will have serious and life-threatening effects on the body, and dialysis or kidney transplantation is needed. Dialysis can also relieve the symptoms and improve the body functions, but kidney dialysis will reduce the quality of life, and long-term dialysis will also produce certain complications, such as nausea, vomiting or low blood pressure. After kidney transplantation, there is no need for artificial dialysis to replace the kidney function, which can improve the quality of life and prolong the life, if there is a chance of kidney transplantation, it is still recommended to do kidney transplantation. Kidney transplantation is not that 100% free of problems, mainly rejection reaction, need to take long-term anti-rejection drugs, there is also a certain chance that there will be a transplantation failure, and then the cost is relatively high, but if you have the conditions, the benefits of kidney transplantation should outweigh the disadvantages.