The causes of T-wave abnormalities on ECG are manifold and can be either physiologic or due to arrhythmias, myocardial ischemia and other diseases. Physiological T-wave abnormalities should pay attention to improving lifestyle, patients with arrhythmia should use anti-arrhythmic drugs, and patients with myocardial ischemia can use calcium channel blockers. 1. Physiological factors: staying up late, emotional stress, drinking alcohol, smoking, etc. can lead to T wave abnormalities. Usually, we should pay attention to ensure enough sleep, keep peace of mind, appropriate exercise, quit smoking and limiting alcohol, and eat more fresh vegetables and fruits. 2. Arrhythmia: Ventricular arrhythmia can lead to abnormal T-wave changes. Antiarrhythmic drugs such as amiodarone can be taken for treatment. It is contraindicated in patients with severe hypotension, abnormal thyroid function, cardiomyopathy, children under 3 years old, and used with caution in patients with hepatic or renal insufficiency. Common adverse reactions include nausea, vomiting, hypothyroidism, bradycardia and pulmonary fibrosis. 3. Myocardial ischemia: patients with chronic myocardial ischemia can have T-wave inversion, and can take verapamil, nifedipine and other calcium channel blockers, which can dilate coronary arteries, relieve coronary artery spasm and improve the blood supply of subendocardial myocardium. Verapamil should not be used in patients with severe bradycardia and high degree of atrioventricular block. Common adverse reactions to calcium channel blockers include edema, constipation, palpitations, and facial flushing. Patients with ECG suggesting T-wave abnormalities should go to the hospital in time to improve the examination and give targeted treatment after clarifying the cause of the disease.