If the condition requires, pioglitazone metformin tablets can generally be taken for a long period of time, but regular review and monitoring is required, and continued use of pioglitazone metformin is not recommended in the event of abnormalities in liver or kidney function or serious complications. Pioglitazone Metformin Tablets are used to improve blood glucose in patients with type 2 diabetes mellitus, and are indicated for patients who are poorly treated with Metformin Hydrochloride alone, as well as patients treated with a combination of Pioglitazone Hydrochloride and Metformin Hydrochloride. Metformin is mainly used to lower blood glucose by inhibiting hepatic glycogen output and increasing the sensitivity of peripheral tissues to insulin. Pioglitazone hydrochloride is an insulin sensitizer and enhances the action of insulin. The combination of the two drugs can be very effective in lowering blood sugar. The drug can be taken for a long time under the supervision of a doctor when the condition requires it. Adverse reactions include nausea, vomiting, diarrhea, mild or moderate edema and headache. If symptoms are evident, dosage reduction or discontinuation of the drug needs to be considered. In addition, signs of lactic acidosis, heart failure, and hypoglycemia should be closely monitored during the medication period, and liver and kidney functions and ophthalmologic examinations should be regularly reviewed, and treatment should be standardized under the guidance of a physician.