Sacubitril is sacubitril valsartan sodium, there is no interaction between sacubitril valsartan sodium and atenolol, it can be taken simultaneously under the supervision of a doctor, but you need to pay attention to adverse reactions and contraindications. The combination of sacubitril valsartan sodium and atenolol can be used in the treatment of chronic heart failure with reduced ejection fraction, while reducing the risk of cardiovascular death and hospitalization for heart failure. However, whether the need for combined medication, combined medication program, need to be a comprehensive assessment by clinicians to give specific medication program, do not add or subtract medication program. After the use of sacubitril valsartan sodium or atenolol, if dizziness, cold extremities, thrombocytopenia, rash, angioedema, hypotension, renal impairment, hyperkalemia and other adverse reactions occur, it is recommended to go to the hospital in time. Sacubitril valsartan sodium is contraindicated in cases of drug hypersensitivity, the presence of severe hepatic insufficiency, and mid- to late-term pregnancy. Atenolol is contraindicated in cases of high heart block, cardiogenic shock, sick sinus syndrome, severe sinus bradycardia. The above drugs need to be used under the supervision of a clinician.