Low differentiated lung adenocarcinoma in advanced stage can be treated by surgical resection, radiotherapy, chemotherapy, targeted therapy and immunotherapy. 1. Surgical resection: for advanced stage with isolated distant metastasis and lesions with surgical opportunity, the disease can be treated by surgical resection, and then supplemented with radiotherapy and chemotherapy after surgery. 2. Radiotherapy: In order to use the energy released by high-energy rays to achieve the purpose of killing tumor cells, it is often combined with chemotherapy and other therapies for joint treatment. 3. Chemotherapy: Systemic therapy in which drugs reach the lesion through blood, such as doxorubicin, cisplatin and other chemotherapeutic drugs. It is often combined with radiotherapy and targeted therapy. 4. Targeted therapy: precise therapy for specific mutation targets, with the advantages of good efficacy and small side effects, commonly used drugs such as erlotinib and gefitinib for EGFR targets. 5. Immunotherapy: Commonly used drugs such as pembrolizumab and atilizumab are therapies to improve the patient’s own immunity. Note that all the above drugs should be applied under the guidance of doctors.