The pain in the middle of the chest like being pressed after waking up is mainly seen in the following causes: first, cardiac causes, if the patient previously had hypertension, diabetes, hyperlipidemia and smoking and other risk factors, the sudden appearance of unexplained pain in the middle of the chest should pay special attention to the onset of coronary heart disease, myocardial ischemia, check the electrocardiogram and cardiac ultrasound, and if necessary, coronary angiography. Second, lung diseases, such as pneumonia, pneumothorax, pulmonary embolism, these patients have preexisting causes, such as low resistance to easy lung infection, patients with pneumothorax may have triggers such as holding heavy objects, strenuous physical activity, and patients with pulmonary embolism may have triggers such as reduced activity of the lower extremities in bed, examination of chest CT and pulmonary artery CTA can help clarify the diagnosis. Third, aortic coarctation, such patients with a long-term history of hypertension will lead to poor blood pressure control, and examination of aortic CTA will help to make a clear diagnosis. Fourthly, although gastritis and gastric ulcer are often evident in discomfort and pain in the stomach area after eating, pain in the middle of the chest is also seen clinically after waking up from sleep, and duodenal bullae or their ulcers are prone to pain in the middle of the chest after waking up from sleep, and gastroscopy helps to diagnose.