Positive antinuclear antibodies usually indicate the presence of an immune disease, such as connective tissue disease, but the specific disease needs to be clearly diagnosed based on your symptoms and a complete antinuclear antibody profile to see which specific antibody indicator is positive. For example, a positive anti-SM antibody or double-stranded DNA antibody in the antinuclear antibody profile suggests the presence of SLE. It is important to note that in some normal people, especially those over 60 years of age, a simple positive antinuclear antibody may also occur. There are also neoplastic diseases, tuberculosis, and kidney diseases that can be positive for antinuclear antibodies and require further testing to clarify the condition. If all other antibodies in the antinuclear antibody profile are negative, there are no abnormalities in complement, C-reactive protein, blood sedimentation, etc., and there are no uncomfortable symptoms, and tumors and tuberculosis are ruled out, the antinuclear antibody can be reviewed regularly.