Recurrent oral blistering should be a clinical symptom of recurrent oral ulcer, recurrent oral ulcer is a common ulcerative injury disease occurring in the oral mucosa, the treatment policy to eliminate the cause of the disease to enhance physical and symptomatic treatment. Treatment method, should adhere to the combination of systemic treatment and local treatment, Chinese and Western medicine treatment, physiological and psychological treatment, symptomatic treatment, oral vitamin B, C, enhance the body’s resistance, help the ulcer healing. Those with obvious pain, more ulcers and shorter intervals can be treated with immunomodulatory drugs such as levamisole, transfer factor and thymidine. Easy can be treated with glucocorticoids, such as prednisone. In addition, systemic treatment is also important, such as giving drugs for sedation and sleep, regulation of nerve and digestive tract functions, medication with 5% gentamicin, cod liver oil paste, 1% hydrocortisone or prednisone paste, and Chinese medicines such as bing bao san, tin type san, nourishing yin and raw fluid san, etc. to prevent stimulation of infection. However, it is not advisable to cauterize the ulcer with carbolic acid or nitrates to avoid damaging healthy tissues.