Rheumatoid disease usually refers to rheumatoid arthritis, with rheumatoid arthritis in the drug during the feeling of weakness may be related to the adverse effects of the drug, most of the rheumatoid arthritis patients will take methotrexate, leflunomide and other immunosuppressants, which can cause fatigue and other adverse effects. Methotrexate and leflunomide are commonly used in rheumatoid arthritis and affect pyrimidine synthesis in activated lymphocytes. They are often indicated in adults with rheumatoid arthritis and have an ameliorative effect. It can usually cause weakness, drowsiness, dizziness, and a potential risk of causing secondary tumors. When rheumatoid arthritis patients feel weak while taking the drug, they should go to the hospital in time, and standardize the treatment under the guidance of the doctor, so as not to delay the condition.