There is no absolute best, fastest or most effective medication for osteoarthritis of the knee. Currently there is no specific drug for treating osteophytes, and the medication is mainly to relieve the symptoms. For knee osteoarthritis, most of the manifestations of localized swelling, pain, and severe may affect the normal joint activities of the knee joint, the general use of medication is mainly to improve the patient’s pain, swelling symptoms. Oral medications are absorbed by the gastrointestinal tract and have a stronger effect than topical medications, while toxic side effects are relatively greater. Commonly used oral drugs include: 1. Non-steroidal anti-inflammatory drugs, such as celecoxib, erliximab, etoricoxib and so on. 2. Opioid analgesics, such as tramadol extended-release tablets. 3. Drugs to relieve joint pain and swelling, such as glucosamine and bisacodyl. Specific drug use program should be in the hospital professional department after consultation with the doctor’s advice to use, should avoid blind self-medication.