Skin signs of syphilis patients: early syphilis skin is usually rose rash or patchy rash, hard chancre, flat warts, etc., late syphilis manifested as permanent damage to the skin mucous membrane. Early syphilis skin is mainly manifested as a generalized rose rash or brown round, oval rash, usually no itching, rash does not merge with each other, early syphilis can subside on its own, after the retreat generally does not leave a scar. It occurs on the trunk, limbs, scrotum, perineum, anus, groin area. Stage 1 syphilis is also characterized by a hard chancre, and stage 2 syphilis can present with skin lesions such as flat warts. Late syphilis is mainly manifested as permanent damage to the skin and mucous membranes of the whole body, syphilis rash, flat warts, alopecia, genital mucous membrane edema, ulceration and so on. And can invade cardiovascular, nervous system and many other tissues and organs, can be life-threatening. After the diagnosis of syphilis, you should go to the hospital in time to check whether the syphilis is early or late, with or without other complications, early treatment, standardized treatment, and regular review after treatment.