There are various causes of pain in female vulvar lips, such as simple vulvitis, vestibulitis, vestibular cysts, etc. It is recommended to go to the hospital for examination and clear diagnosis for targeted treatment. 1. Simple vulvovaginitis: patients can show vulvar congestion, swelling, vesicles, ulcers, vulvar burning, itching, pain, etc., usually especially during urination. Antibiotics are usually chosen for treatment, and commonly used drugs include gentamycin, tetracycline hydrochloride, erythromycin and so on. 2. Vestibulodynia: Vestibulodynia is usually characterized by redness, swelling, pain, and burning sensation in the affected vulva, and is often treated with broad-spectrum antibiotics, commonly used drugs include metronidazole, cefadroxil, and levofloxacin. Patients with abscess formation can also choose surgical treatment along with medication. 3. Vestibular cysts: small cysts usually have no obvious symptoms, but large cysts will be manifested as vulvar swelling, pain in the affected area, pain during sexual intercourse and so on. Treatment is often combined with surgical treatment, drugs often choose broad-spectrum antibiotics, such as cefadroxil, levofloxacin, tinidazole and so on. Surgical methods include incision and drainage, vestibular cystostomy, and glandular resection. Women with pain in the external lip, it is recommended to consult a doctor in time to clarify the cause of the disease, and actively treat the symptoms.