Severe mitral regurgitation is commonly associated with mitral valve insufficiency, which requires active clinical treatment, based on the results of chest X-ray, electrocardiogram, echocardiogram and other tests to clarify the cause and combine with clinical symptoms to develop a treatment plan. The treatment is mainly the following: 1, drug therapy is mainly symptomatic treatment, if accompanied by hypertension can be given vasodilator drugs, combined with heart failure and not suitable for surgery patients, the use of ACEI class captopril or ARB class drugs such as valsartan. Digitalis drugs such as cetiran and digoxin can be used for heart failure with rapid atrial fibrillation, and anticoagulation therapy is required if there is a history of embolism and thrombus in the atria.2. Surgery can be performed for severe mitral regurgitation that is clearly due to heart valve disease, and surgical treatment is mainly surgical, including mitral valve repair and mitral valve replacement.3. Minimally invasive interventional therapy has progressed relatively rapidly in recent years, such as transcatheter mitral cyanosis clamping. Minimally invasive interventions such as transcatheter mitral cyanosis clamping, percutaneous coronary sinus prosthetic annuloplasty, etc.