Parkinson’s disease was previously thought of as a disease of the elderly. In fact, in recent years there has been a trend toward a younger age of onset of this disease, and middle-aged Parkinson’s disease patients in their 40s and 50s can often be seen. When Parkinson’s disease patients develop symptoms such as hand tremors, the dopamine cells in the brain have already begun to be affected, so many Parkinson’s disease experts believe that the only way to benefit from Parkinson’s disease is early detection and early treatment. The following are the seven precursor symptoms of Parkinson’s disease. Once you experience one or more of these symptoms, you should pay attention and seek medical attention. 1. Loss of sense of smell and constipation. This is the most important and promising early warning sign of Parkinson’s disease. You may find that your sense of smell is not as sensitive as before, even the smell of bananas, pickles, spices, and your normal bowel habits have changed (but you should exclude changes in bowel habits caused by diet, medications, or other diseases). 2. Tremor in the arms or other parts of the body. There are many clinical diseases that can cause tremor, but the typical tremor in Parkinson’s disease is “no tremor when moving, appears when quiet, and intensifies when nervous”, and the “pill-rolling” movement of the thumb and index finger often occurs, so you should be more alert. 3. Difficulty in moving or walking. The stiffness of the body, upper limbs or lower limbs starts to feel stiff and does not go away even after moving. Your arms do not swing properly when you walk, or people may say that you look stiff when you walk. 4. Slower movements and smaller writing. If you notice that your movements such as buttoning, putting on socks, or tying your shoes are significantly slower, or that your writing is getting smaller, this may be an early sign of Parkinson’s disease. 5. Small arm swing and mask face. When walking, the swing of one arm is smaller than the swing of the other, which may also be a sign of early Parkinson’s disease. When the movement disorder occurs in the face, it is as if the patient is wearing a false mask, with a dull expression, reduced blinking, and eyes staring forward, which is medically known as “mask face”. 6. Depression. About 40-55% of Parkinson’s disease patients will be depressed, manifested as easy fatigue, loss of interest, loss of appetite, lack of confidence, emotional instability and other symptoms. Depression can appear at any stage of Parkinson’s disease, but there are two peaks, the first peak is at the beginning of the disease, catching this early signal is very important for the prevention and treatment of Parkinson’s. 7. sleep disorders. 70% of Parkinson’s patients have various sleep disorders. These include excessive daytime sleepiness, nighttime awakenings and violent movements such as punching, kicking and yelling during sleep. Of course, if you have one or more of these symptoms, it does not necessarily mean that you have Parkinson’s disease. It is recommended that you go to a regular hospital neurology outpatient clinic for Parkinson’s disease examination to clarify the diagnosis for further correct treatment. For patients with confirmed Parkinson’s disease, it is recommended that you choose medications according to the recommendations of the Parkinson’s disease treatment guidelines of authoritative academic institutions at home and abroad: for example, non-ergot dopamine agonists (e.g., pramipexole, rotigotine, etc.), monoamine oxidase type B inhibitors, etc. can effectively improve symptoms and quality of life; and paracetamol can delay the occurrence of motor complications and improve the accompanying depressive symptoms, and can be be used as a starting drug for patients with Parkinson’s disease.