Neck wrinkles are a chronic progressive aging problem of the neck skin, which usually develops gradually after the age of 25. The causes are complex, mainly including heredity, photoaging, age, and quality of life. The mechanism of neck wrinkles is the reduction of subcutaneous collagen and fibroblasts, followed by the reorganization of subcutaneous fibers or even fracture, which is manifested as neck skin laxity, sagging and deep static wrinkles, i.e., neck wrinkles. The depth and extent of lesions are also related to mental stress, late night, exertion and systemic diseases. With the improvement of living standards, neck wrinkles have a certain impact on the patient’s work, life, mental health and quality of life, so it is more and more important. Currently, there are many clinical treatments for neckline, including medication, laser and surgery, but the overall efficacy is unsatisfactory due to the long treatment cycle, poor patient compliance and postoperative complications. This time, we will take the “water light needle” + “micro-needle therapy” medical treatment to see if the final treatment effect can satisfy people. I. Subjects The 150 cases of neckline treatment are all from our hospital. Exclusion criteria: ① People with mental, blood and other systemic diseases or serious skin diseases; people with a history of photosensitivity or allergy to the test products. ② Those who have undergone fruit acid treatment and excessive sun exposure within one month. ③Those who have used or taken anticoagulants or retinoids internally within 2 months. ③Pregnant or breastfeeding women and those who are unable to follow the doctor’s instructions to return to the clinic on time. All candidates signed an informed consent form before treatment, and were photographed before and after treatment, and randomly divided into groups A, B, and C. Group A: 50 cases, age 22-60 years old, average 33 years old; Group B: 50 cases, age 22-60 years old, average 36 years old; Group C: 50 cases, age 22-60 years old, average 37 years old. Group C: 50 cases, age 22-60 years old, average 37 years old. The general information of the three groups of patients are not statistically different, and are comparable. Second, the choice of medical instrument Hydrographic needle injector: nutrients for hyaluronic acid. Roller micro-needle: the nutrients are collagen and hyaluronic acid, EGF (epidermal growth factor), aFGF (acidic fibroblast growth factor), bFGF (basic fibroblast growth factor) and so on. Treatment process: Group A patients were treated with microneedling and hydrafacial injection; Group B patients were treated with microneedling; Group C patients were treated with hydrafacial injection; each treatment interval for each group was 28-35 days, with a total of 5 treatments. All candidates were routinely cleaned before each treatment, and then the fixed personnel used a fixed machine to take pictures of the front, left and right sides at 45° and 90° in a fixed room. Before treatment, all three groups of candidates were treated with topical compound lidocaine cream on the neck, which was sealed with plastic wrap for 40 minutes, and then local iodine-vapor disinfection was applied to the neck in the lying position. Candidates in Group A: (1) Freeze-dried powder mixture 1 in Flat Neck Lines Enhancement Combination was injected evenly into the subcutaneous tissue of the neck lines with a 1 ml syringe in a point shape; (2) Micro-needle roller was used from bottom to top and left to right, and cross manipulation could be adopted to ensure coverage of the treatment area and make the skin slightly red, and at the same time, Freeze-dried powder mixture 2 was introduced to promote its complete absorption; (3) Hyaluronic acid was injected into the skin of the neck by using hydrazolizer with 3 ml of hyaluronic acid. into the neck skin. Candidates in group B used the first two steps of the above operation, while candidates in group C only used the third step of the above operation. During the operation, we observed the skin reaction of the candidates and asked them about the degree of pain in order to adjust the operation strength and depth. After the operation, all the candidates used the refrigerated medical collagen repair film and were asked to pay attention to the moisturizing of the face and sun protection during the treatment. Determination method Before the treatment and 1 month after the end of the treatment, the treating doctor and the applicant communicate together to evaluate the neckline visually, compare the photos and measure the depth and length manually. Basic cure: comprehensive assessment of neckline area subsides ≥90%, neck obviously firm and smooth; obvious effect: neckline area subsides 60-89%, neck laxity improvement is more obvious; effective: neckline area subsides 30%-59%, ineffective: neckline area subsides <30%, neck skin does not see obvious improvement, before and after the treatment, there is no obvious change. The total effective rate is the sum of the basic cure rate, significant rate and effective rate. V. Treatment results Comparison of therapeutic efficacy: The study found that there is a significant difference in the therapeutic effect of the three groups, in which the therapeutic efficacy of using microneedle therapy for group A and B candidates is significantly higher than that of group C who used hydrographic therapy alone, in particular, the effective rate of the combined therapy reaches 100%. And with the increase in the number of treatments, the effective rate of groups A and B also increased, i.e., the more the total number of treatments, the higher the effective rate, and the better the treatment effect will become. The relationship between therapeutic effect and the number of treatments: observation of the treatment results show that in the entire course of five treatments, the use of microneedle therapy of group A, B candidates with the number of treatments for neckline reduction rate is proportional to the number of treatments, that is, with the increase in the number of treatments, the efficacy of the treatment is correspondingly better. Adverse reactions In the course of treatment, some candidates appeared redness of the skin in the treatment area within three days after treatment, which was improved after local use of medical sterile repair mask. All candidates did not appear after the treatment of hyperpigmentation, no allergic dermatitis, scarring and other adverse reactions. Tips: In recent years, with the improvement of living standards, people's pursuit of beauty is increasing, the neck skin problems are also more and more attention, especially neck lines. The cause is more complex, heredity, earth's gravity, light aging, bad habits and skin aging, etc. all affect the occurrence and development of neck wrinkles, which further affects the physical and mental health of the candidate and the quality of life. At present, the treatment of neckline is varied, often using laser, drugs, physical and epidermal peeling, but the efficacy is not very satisfactory, so the choice of microneedle combined with the comprehensive therapy of hydrolight injection. Microneedle therapy, also known as "microneedling" and "mesotherapy", originated in France and was first applied to clinical treatment by Dr. Michel Pistor, a physician, in 1952. In recent years, it has been used for skin rejuvenation, localized static wrinkles, etc. The principle is to use micro-needles to cross the skin barrier of the stratum corneum, to establish a large number of tiny skin micro-channels in the epidermal layer without destroying its integrity, and to promote the penetration of drugs. The rapid delivery of bioactive substances and growth factors, etc. through the micropores enhances product absorption. Roller micro-needling uses nutrients mainly composed of collagen and hyaluronic acid, EGF (Epidermal Growth Factor), aFGF (Acidic Fibroblast Growth Factor), bFGF (Basic Fibroblast Growth Factor), etc., which effectively stimulate the regeneration of dermal collagen, hyaluronic acid and fibroblasts, and can restructure and regenerate the broken fibers in the dermis at the neckline. At the same time, the micro-needle roller can also stimulate collagen fiber proliferation in the dermis, promote skin metabolism, strengthen the skin's self-healing ability to achieve the corresponding effect. Microneedling has been proven to be effective in solving cosmetic skin problems such as acne, skin pigmentation, scars, wrinkles and facial rejuvenation. In this study, we observed the efficacy of microneedle hydrotherapy in the treatment of neckline, and compared the total effective rate after treatment and the rate of neckline reduction after each specific treatment in treatment group A and control groups B and C. The results were summarized as follows After a total of 5 treatments, the effective rate of group A was as high as 100%, and group B was 92%, both significantly higher than the 20% of group C. The difference between the groups was statistically significant (p<0.05); and it was also found that the tightness and smoothness of the neck skin of the candidates using microneedle therapy was significantly higher than that of the group using only the hydrographic injections; and it became more and more obvious with the increase in the number of treatments. Therefore, we believe that microneedling combined with hydrafacial injection for the treatment of neck wrinkles has a definite efficacy and rare adverse effects, and can be recommended as a more ideal method for the treatment of neck wrinkles.