Plasma cells are immune cells, and plasma cell infiltration refers to the presence of chronic inflammatory or neoplastic diseases in the body. Plasma cells, also known as effector B cells, are cells in the immune system that release a large number of antibodies. If there is an abnormality in the body, the number of plasma cells will increase and infiltration will occur, which is usually seen in chronic inflammatory and tumor diseases, and the cause of plasma cell infiltration should be clarified at an early stage for early treatment. Plasma cells have the function of synthesizing and storing antibodies, and participate in the humoral immune response. If the plasma cell infiltration is caused by inflammation, it can be treated by medication, such as cephalosporin and penicillin; if it is a neoplastic disease, it can be treated by surgery, radiotherapy and so on. Daily attention should be paid to rest, maintain an optimistic state of mind, regular monitoring of plasma cells, medication please follow the doctor’s instructions.