Under and over sex chromosomes are both serious, both are chromosomal disorders, which may lead to malformation or absence of fetal sex organs, affecting sex life and pregnancy, as well as causing delayed brain development, severe mental retardation and other problems, which are more painful for the affected child and fatal to the family. Normal human sex chromosome is XY or XX, when the sex chromosome is X less one, it is Turner syndrome, the main manifestation of the child is short stature, the secondary sexual characteristics of the stunted or undeveloped. When the sex chromosome is XY or XX, it is called Turner syndrome, which is characterized by short stature, underdevelopment of secondary sex characteristics, or failure to develop. Further amniocentesis is recommended to confirm the diagnosis and to determine the quality of the child’s future development and survival. If discomfort occurs in late pregnancy, timely consultation and active treatment are required to avoid delay.