The causes of total bilirubin 263μmol/l mainly include liver and gallbladder diseases or physiological factors such as staying up late, drinking alcohol, etc., which can be treated by improving living habits, taking medication or surgery. 1. Improve living habits: patients with total bilirubin 263μmol/l should avoid staying up late, alcoholism, overwork, etc., quit smoking and drinking, increase exercise, drink more water, and enhance their immunity. At the same time, pay attention to a light diet, balanced nutrition, avoid eating fried, animal offal and other high-fat food. 2. Take medicines: If it is caused by viral hepatitis, you can take antiviral medicines such as acyclovir to treat it; if it is caused by alcoholic liver and fatty liver, you can take medicines such as silymarin and reduced glutathione to protect liver cells. If it is caused by cholecystitis, gallbladder stones, etc., antibiotics such as norfloxacin can be taken for anti-infection treatment, and ursodeoxycholic acid and other choleretic drugs can also be taken. If it is caused by hemolytic anemia and other hemolytic diseases, it can be treated by supplementing folic acid, iron, taking methylprednisolone and other glucocorticoid drugs or cyclophosphamide and other immunosuppressive drugs. 3. Surgery: If the disease is caused by gallbladder stones, bile duct stones, etc., surgery can be performed to remove the stones if necessary. If the patient has high total bilirubin for a long time or repeatedly, it is recommended to consult a doctor in time to identify the cause of the disease and carry out targeted treatment. The medication should be taken strictly according to the doctor’s prescription, and should not be used on its own, so as not to delay or even aggravate the condition.