3+3 is an indicator of tumor malignancy, not a staging indicator. Gleason score is based on the degree of glandular differentiation and tumor growth in the mesenchyme as the grading criteria to evaluate the degree of malignancy of the tumor, and at the same time, the prostate cancer tissues are divided into primary grading area and secondary grading area, the primary grading area refers to the growth pattern that occupies the dominant area, and the secondary grading area refers to the growth pattern that doesn’t occupy the dominant area but at least occupies more than 5% of the area. The Gleason score is the sum of the histologic grade of the most common form of cancer growth plus the second most common histologic grade.The Gleason score generally ranges from 2-10, with 1+1=2 for the best differentiated and 5+5=10 for the worst. Prostate cancer patients also need to pay attention to the patient’s age, physical condition, and PSA. Patients need to visit the clinic for examination and early treatment if they are not feeling well.