Staying up late often is particularly bad for health. 1. If patients stay up late often, it will cause serious neurological damage, leading to strong cerebral vasospasm, ischemia, insufficient blood supply, TIA attacks, or increased incidence of acute cerebrovascular disease caused by inadequate blood supply to the vertebral basilar artery, which can lead to cerebral hemorrhage, cerebral infarction, cerebral embolism, cerebral infarction and other serious cerebrovascular diseases. 2. The patient often stay up late, will lead to a significant increase in blood pressure, and the emergence of hypertensive emergencies and hypertensive crisis. 3, often stay up late will lead to the heart arteries, such as coronary arteries, a significant shortage of blood supply, will lead to myocardial ischemia and myocarditis, pericarditis and other serious heart disease. 4, often stay up late will also appear endocrine disorders, and endocrine disruption syndrome.