Always sleeping with eyes open may be caused by normal physiological phenomenon, protruding eyeballs, facial nerve paralysis, etc. Different causes have different treatments. 1. Normal physiological phenomenon: Teenagers or children sleep with their eyes open due to a decrease in orbicularis oculi muscle tone during sleep, this is a normal physiological phenomenon, and the symptoms will be relieved as they grow up. 2. Protruding eyeballs: Hyperthyroidism can lead to protruding eyeballs, with a disproportion between the inner volume of the eyelids and the eyeballs, and the eyelids are unable to cover the eyeballs, resulting in incomplete eyelid closure. The patient may also be accompanied by panic, hand tremor, emaciation and other discomforts, which can be clearly diagnosed by thyroid function tests. 3. Facial nerve palsy: Facial nerve palsy patients may have motor dysfunction of facial expression muscles, and the sick side can not make frown, frowning, closed eyes, puffing and pouting and other discomfort symptoms. It is recommended that patients who have difficulty in closing their eyes and other discomforts should consult a doctor to evaluate their condition and follow the doctor’s instructions for treatment.