The efficacy of spironolactone tablets is diuretic, and the side effects include hyperkalemia, gastrointestinal reaction, hyponatremia, endocrine system abnormality, and central nervous system abnormality. Spironolactone Tablet is a competitive inhibitor of aldosterone, acting on the distal convoluted tubules and collecting ducts, exerting diuretic effects, and clinically used in edematous diseases such as cirrhotic ascites, renal edema, congestive edema, as well as in the treatment of hypertension, primary aldosteronism, and also in the prevention of hyperkalemia. The common adverse reactions of this drug are hyperkalemia, and gastrointestinal reactions such as nausea, vomiting, stomach cramps, diarrhea, etc. Rarely seen are side effects such as endocrine system abnormalities (gynecomastia, gynecomastia, voice coarsening, etc.), central nervous system abnormalities (such as walking incoordination, headache, etc.), hyponatremia, and rarely allergic reactions, hyperchloremic acidosis. It should be noted that the use of spironolactone tablets is prohibited in patients who are allergic to any component of the drug and in patients with hyperkalemia. Patients should use spironolactone tablets in accordance with the doctor’s instructions and avoid blindly using the drug on their own to avoid side effects.