Multiple myeloma cough may be caused by a combination of respiratory infections. The etiology and pathogenesis of multiple myeloma are not clear, the triggers include obesity, gene mutation, etc. The main manifestations are anemia, bone pain, renal insufficiency, infection, bleeding, neurological symptoms, hypercalcemia, amyloidosis, etc. Coughing may be caused by the combination of respiratory infections with low immunity and inflammation stimulating the spasm of trachea, which leads to coughing discomfort. Pay attention to rest to avoid exertion, strengthen nutrition, increase body resistance, it is recommended to go to the regular hospital in time for examination, according to the results of the examination to choose the appropriate drug treatment. Under the guidance of the doctor, the use of medication such as bortezomib, lenalidomide, cyclophosphamide, dexamethasone, and anti-inflammatory drugs such as cefixime dispersible tablets, aminobromine hydrochloride tablets, etc. Targeted treatment, timely review, do not self-medication in order to avoid causing adverse effects. If you feel unwell, you should go to the hospital in time, and under the guidance of the physician, give targeted treatment after clarifying the cause.