Every day is unhappy very depressed, in the clinical highly suspected to belong to depression, depression is a kind of happy, low mood, depression-based content, accompanied by a slow brain response, no expectations for the future, relatively low self-esteem, and patients often lack of interest and fun, the morning up to feel a day of pain hard to live like years, patients feel no meaning to live, and even have self-injury, suicide Patients feel that there is no point in living, and even have self-injury and suicidal thoughts and behaviors. On the one hand, this may be a state of brain dysfunction, which can be treated clinically with 5-hydroxytryptamine, norepinephrine and dopamine, which can regulate this state of depression; on the other hand, when this kind of mood, unhappiness and depression occurs, it may be due to neurotransmitter disorders, and the symptoms can be well improved with systematic antidepressant treatment.