Seborrheic keratosis has no special symptoms and generally does not require treatment. If rapid growth, redness, swelling, ulceration, pain and other discomforts occur, cryotherapy may be an option, and the number of times cryotherapy is required cannot be determined due to individual differences. Seborrheic keratosis, commonly known as “age spots”, is a common benign tumor of the skin, usually manifested as slightly above the surface of the skin, brown oval papules or plaques. One of the most common treatments is cryotherapy, which uses liquid nitrogen to destroy tissue cells at low temperatures. The results are outstanding, but the number and duration of treatments vary depending on the severity of the patient’s symptoms. Cryotherapy may cause scarring, pigmentation changes and other adverse reactions, patients need to consult the dermatology department of the hospital to formulate a reasonable treatment plan for individual conditions to prevent over-treatment and mistreatment.