Herpes simplex oozing yellow fluid may be in the self-healing stage and there is usually no need to worry and keep the area clean. If the condition worsens, general treatment and medication are needed to improve the condition. 1. General treatment: For patients with herpes simplex oozing yellow fluid, keep the local area clean, use clean cotton swabs to gently swab away the fluid, avoid rubbing, picking and scratching the affected area to prevent secondary infection. It is recommended that patients cover the lesions with cold, wet dressings to help reduce swelling and promote lesion healing. 2. Medication: Patients can take oral antiviral drugs as prescribed by the doctor, including acyclovir and valacyclovir, which can inhibit viral proliferation. If secondary bacterial infection occurs, you need to follow the doctor’s instructions to apply mupirocin, fusidic acid and other antibiotic drugs, to help kill bacteria and anti-inflammatory. If the herpes simplex patient lesions oozing yellow liquid, need to keep local clean, suggest that the patient to go to the regular hospital, with the doctor for standardized treatment. Drugs need to be used in accordance with medical advice.