Widespread erythematous infiltrative damage with desquamation is known as erythroderma. Erythroderma, also known as exfoliative dermatitis, is a serious systemic disease. It is generally considered to be the same disease as exfoliative dermatitis, with the former characterized by extensive and marked erythematous infiltrative damage with furfuraceous desquamation, and the latter by the presence of extensive edematous erythema accompanied by copious desquamation. Since the flaking is sometimes not obvious in this disease, the former is considered a better and more generic name. Skin involvement of ≥90% is a prerequisite for the diagnosis of the disease. Prevention of extensive erythematous infiltrative damage with desquamation: (1) The patient should rest in bed during the onset of the disease, and it is better to live in a single room. Keep the room warm and pay attention to air circulation. (2) Give high protein fluid or semi-fluid diet. (3) For those with vesicosis and oozing fluid, pay attention to oral and vulvar hygiene, and change clean bedding in time to prevent infection. (4) If the condition is serious and coma occurs, both hands should wear gloves to avoid scratching the skin. Nursing methods for extensive erythema infiltrate damage with flaking: (1) Strengthening and rationalizing the use of supportive therapy is the key to treating this disease. Pay attention to the supplementation of water, protein, potassium and calcium as well as vitamin supplementation. Due to the large amount of flaking, patients with erythroderma lose a lot of protein, and should be supplemented with sufficient protein in the daily fluid intake, in order to facilitate the recovery of the body. Diet should be given easy to digest and nutritious food. Such as fresh vegetables, fruits contain a lot of vitamin C and fiber, can enhance the patient’s resistance to disease, and can play the role of laxative, discharge toxins; lean meat, eggs can be supplemented with protein, are conducive to the recovery of the skin lesions, is the first choice of food for patients with red skin. Mutton, seafood, chili peppers, parsnips, leeks, cigarettes, alcohol and other spicy stimulation and fishy hair should be avoided, so as not to aggravate the condition. Most of the patients with erythroderma loss of appetite, should be reasonable with food, tasty and rich, but also can not be too much intake. (2) Pay close attention to the movement of infection and apply antimicrobials when necessary to avoid the spread of infection and the occurrence of sepsis. Nursing staff should be in good health, reduce the number of visitors, especially should avoid cold, enteritis and other patients to visit or care for patients with erythroderma. (3) Pay attention to the rinsing of the mouth, eyes and perineum. Gargle with 2%~3% boric acid water or 1% hydrogen peroxide, 1:1,000 gentamycin solution, four times a day, and apply 1%~2% gentian violet solution to the ulcerated area; eye care is crucial, 3~4 times a day, rinse the eyes with 3% boric acid water, and then order 0.25% gentamycin ophthalmic ointment or cortisone ophthalmic ointment; perineum can be used every day with cyperus rotundus and ginseng, and decoction of 200 ml of water, and then warmly wash the affected area. (4) It is advisable to live in a single room with good ventilation, maintain a certain temperature and humidity, and pay attention to keep warm in winter. To maintain a relatively sterile environment, often use ultraviolet light to disinfect, often change the disinfection sheet. Strengthen the skin care, swelling and oozing obvious people can use the raw ground elm 30g, cypress 30g, horse chestnut 60g, decoction cold compress. 1~2 times a day, 30 minutes each time; dry and cracked and a lot of flaking can be used to non-irritating sesame oil to rub the skin.