High fever after vaccination may be an adverse reaction after vaccination, or it may be caused by colds and other factors. If the fever exceeds 38.5℃, the cause of fever should be clarified under the guidance of professional doctors and antipyretic drugs (such as ibuprofen, etc.) should be taken, together with physical hypothermia. If there is an adverse reaction after vaccination, causing high fever, fever-reducing treatment should be carried out under the guidance of a specialized doctor, and commonly used antipyretic drugs include ibuprofen, acetaminophen, and so on. Physical cooling can also be done, such as wiping the neck, armpits, palms, feet and groin with a hot towel, or using fever-reducing patches. If you have a high fever due to a cold after vaccination, you should not only treat the fever by lowering the temperature physically or by taking fever-reducing medications such as ibuprofen, but also take anti-viral medications such as aminoglutethimide capsules and oseltamivir under your doctor’s supervision. If the fever is caused by vaccination, but the fever does not exceed 38.5 ℃, you can first carry out physical cooling, temporary observation, most of them will be relieved in 2~3 days. For high fever caused by vaccination, it is recommended to go to the regular hospital as soon as possible, and the professional doctor will take measures to reduce the fever in time. During the fever period, pay attention to drink more water, can accelerate the body’s metabolism, promote the absorption of drugs, accelerate the fever.