Chemotherapy drugs used in hospitals for oncology patients are prepared by nurses. In the process of preparation, if they are not handled properly and enter the human body through skin contact, respiratory inhalation and other ways, they will make the human body affected by low doses of drugs and cause some hazards to the health of nurses as follows, such as hair loss, blood cell damage, allergic reactions, menstrual abnormalities, DNA damage, airway damage, etc. 1. Hair loss: Hair loss is toxic reaction of chemotherapy drugs on the skin. Long-term intake of chemotherapy drugs in small doses can affect the division and growth of hair follicle cells, resulting in the death of hair growth layer cells and hair loss; 2, blood cell damage: the majority of antitumor chemotherapy drugs have the toxic effect of myelosuppression, especially cyclophosphamide, adriamycin, platinum agents, etc., have a very serious myelosuppressive effect, even a small amount into the body will lead to the bone marrow hematopoietic function is affected, manifested as white blood cells Decrease, with the accumulation of time, red blood cells and white blood cells will also cause damage; 3, allergic reactions: some nurses in hypersensitive state may have allergic reactions after exposure to certain chemotherapeutic drugs. Nurses whose skin mucosa is often in contact with chemotherapy drugs will inevitably have drugs sprayed on the skin, causing local skin irritation symptoms such as erythema and ulcers; 4. Menstrual abnormalities: chemotherapy drugs such as cyclophosphamide and vincristine can cause primary ovarian failure and amenorrhea; 5. DNA damage: damage to peripheral blood lymphocyte DNA by antitumor drugs can lead to lymphocyte chromosome mutations, The damage to DNA of peripheral blood lymphocytes caused by antitumor drugs can lead to chromosomal mutation, sister chromosome swap or DNA break, which can even be inherited to fetus and lead to fetal malformation; 6. Airway damage: some chemotherapy drugs may evaporate and be inhaled into airway by nurses, leading to respiratory mucous membrane discomfort or even damage. In addition, antineoplastic drugs can also operate through the placenta, causing intrauterine distress of the fetus or embryo. Preliminary investigations have shown that occupational exposure to antineoplastic drugs during pregnancy has adverse effects on physiological functions. Therefore, nurses should be well protected when dispensing chemotherapy drugs. Wear masks, hats, double gloves, and use special biosafety cabinets for dispensing.