Bone non-union is one of the common complications after humerus stem fracture, usually considered humerus stem fracture generally 6-8 weeks to heal, if there is still no sign of healing after 24 weeks, then it can be diagnosed as bone non-union (also called bone non-union). Data show that in the United States about one in ten patients with bone nonunion, bone nonunion leads to the patient’s injured limb dysfunction, and has a greater impact on daily work and life. Therefore, the study of bone nonunion should attract our attention. Bone non-union causes analysis: I. Fixation unreasonable or imperfect 1, loose after splint or plaster fixation, fracture re-displacement; 2, poor choice of internal fixation; 3, internal fixation technology error. Poorly displaced 1. Poorly displaced fracture with gap or bone defect at the broken end has a great impact on fracture stability and directly affects fracture healing. 2, excessive traction, muscle pulling or soft tissue embedded in the broken end, so that the fracture end of the gap exists, can also cause the fracture does not heal. Third, local blood flow obstacles 1, rough manipulation, repeated multiple revision and severe trauma lead to soft tissue and blood vessel injury around the fracture, affecting the blood flow of the fracture end, causing the fracture not to heal. 2.Surgery leads to more periosteal stripping, large soft tissue damage, and serious damage to blood transport, resulting in non-union of bone. Therefore, surgery should minimize periosteal stripping, i.e. “minimally invasive surgery”. Infection factors: Infection increases necrosis of the fracture end, affects blood circulation and the formation of bone scab, and leads to delayed fracture healing or even non-healing of the bone. Functional exercise is inappropriate and wrong When the fracture end is not firmly fixed, or premature activity of the injured limb, it will affect the stability of the fracture end, which may lead to non-union of the fracture. Therefore, when the fracture occurs, such as: humeral stem fracture 6-10 weeks, imaging examination shows that the bone scab growth is slow or the bone scab has the phenomenon of resorption, or no bone scab growth, such as timely detection, should take measures to deal with the cause of the disease, or the application of drugs to promote bone healing, in order to avoid the occurrence of bone non-union. The treatment of non-healing bone: Chinese medicine identification and typing: 1, evidence type: blood stasis and collateral blockage type Treatment: activate blood stasis, connecting the bone and renewing the tendon. Treatment: activate blood stasis, remove blood stasis, connect the bones and reinforce the tendons. Composition: ripened earth, angelica, red peony, chuanxiong, rhizoma ligustici, tuyuan, dilong, chuanjian, boneset, scutellaria, chenpi, licorice. 2. Type of evidence: positive deficiency and blood stasis type. Treatment: supporting the positive and nourishing the blood, activating the blood and connecting the bones. Formula: Angelica sinensis blood tonic soup with flavor. Composition: Angelica sinensis, Radix Astragali, Radix Astragali, Radix Chuanjie, Radix Paeoniae Alba, Radix et Rhizoma Dioscoreae, Radix et Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae. Evidence type: evil poison and stagnation type Treatment: clearing away heat and removing toxins, activating blood circulation and removing blood stasis. Prescription: five flavors disinfectant drink plus flavor. Drug composition: honeysuckle wild chrysanthemum, purple flowers, red peony, Angelica sinensis, Tuyuan, centipede, preparation of fragrant herbs, licorice. If the evil poison is gradually eliminated and the positive qi is deficient, it is necessary to support the positive and eliminate the evil, activate the blood and connect the bones, and add flavoring to Tori Pus Dispensary. In the early stage of fracture, we should follow the principle of “reasonable, minimally invasive, painless, economical and safe” to restore the continuity and mechanical integrity of bones and ensure the effectiveness of fixation. In recent years, we have used minimally invasive surgery, axial fixation, such as intramedullary nail fixation technique, Kirschner pin fixation, etc., or if necessary, combined with splinting external fixation for 4-6 weeks, triangular towel suspension to reduce the activities, to avoid separation of the broken ends to treat closed humeral stem fracture, and all of them have achieved good healing. Humerus fracture does not heal or humeral stem fracture after 6-10 weeks, imaging examination suggests that the bone scab has no growth or slow growth; local soft tissue injury is heavy or there are many times the fracture of the whole patient, should attract attention, should actively take measures to eliminate the cause of the disease, to prevent the possibility of bone non-union. Application of preventive measures: 1, local injection of autologous bone marrow blood cells; 2, local injection of bone marrow blood extracted stem cells; 3, local multi-point injection of fracture healing stimulating hormone; 4, combined application of the above methods. Shockwave therapy: It has better efficacy in the early stage of fracture non-union. In case of failure of internal fixation treatment, such as broken and loose steel plate, internal fixation should be adjusted in time, such as changing eccentric fixation to central fixation, but bone grafting is necessary and the principle of rich bone grafting inside and outside of the medulla should be followed. If open fracture, bone loss, time within 6-8 hours of light pollution, should be in the premise of thorough debridement, and strive to complete the fixation and bone grafting in one phase to ensure fracture healing. If the open fracture, heavy injury and pollution, often use external fixation therapy. Especially in patients with combined infection, deformity, shortening or bone defects, repeated surgery is often required, and postoperative period often brings serious complications to patients. If bone non-union occurs, specific problems, specific analysis, individualized treatment principles should be adopted, such as good reset, small trauma, solid fixation, protection of soft tissues and blood flow, if necessary, joint use of a variety of therapeutic methods, to promote the early healing of the non-union of the bone, in order to achieve a satisfactory therapeutic effect.