Lymph is one of the common spreading locations of esophageal cancer in late stage, accounting for about 2/3 of the cases. middle esophageal cancer often metastasizes to paraesophageal or hilar lymph nodes, and may also metastasize to lymph nodes of the neck, peripancreatic area, and left gastric artery. Lower esophageal cancer can often metastasize to paraesophageal lymph nodes, paracentral lymph nodes, paracentral lymph nodes of left gastric artery and abdominal cavity, and occasionally to upper mediastinal lymph nodes and cervical lymph nodes. The lymphatic metastases are to the septum, abdomen, trachea and paratrachea, hilar and parabronchial in order. The neighboring organs of esophagus are often the first choice for esophageal cancer spreading, and cancer cells directly infiltrate, upper esophageal cancer can invade into larynx, trachea and soft tissues of neck, and even invade into bronchus to form bronchial-esophageal fistula; and also invade into thoracic duct, chiatic vein, hilum and lung tissues, and the spreading symptom of esophageal cancer is that part of esophageal cancer can invade into the aorta to form esophageal-aortic fistula, which can cause haemorrhage and cause distant. Lower esophageal cancer can often involve cardia and pericardium. In the late stage of esophageal cancer, the spreading location is also easy to appear in the wall of esophagus, and the underlying cells of the epithelium next to the esophageal cancer become cancerous or carcinoma in situ, which is one of the ways of surface spreading of the cancerous tumor. Cancer cells often do not infiltrate the lymphatic vessels in the submucosal layer of the lamina propria of the esophagus. The symptoms of spread of esophageal cancer are mostly seen in advanced stage patients. The most common metastases are to liver (about 1/4) and lung (about 1/5), and other organs are bone, kidney, adrenal gland, pleura, omentum, pancreas, heart, lungs, thyroid gland and brain in order.