Acute epiglottitis requires hospitalization and prompt medical attention is recommended for symptomatic management. The main causative organism of acute epiglottitis is Haemophilus influenzae type B. This causative organism is very strong and can cause acute edema of the epiglottic laryngeal and lingual surfaces within a short period of time, and the epiglottis is visibly bulging. As the disease progresses, the patient may experience significant dyspnea and dyspnea, which may lead to asphyxia in severe cases. The patient’s life may be in danger at any time and hospitalization is usually required for treatment. Patients with acute epiglottitis should be hospitalized to pay close attention to the patient’s respiratory changes and keep the airway open. Adequate antibiotics, such as penicillin, ceftazidime, etc.; adequate glucocorticoids, such as dexamethasone, methylprednisolone and other drugs can be selected for treatment. Local nebulizer treatment to keep the airway moist, thin sputum and anti-inflammatory, commonly used gentamicin, dexamethasone, alpha chymotrypsin and other drugs. Drugs must be applied under the guidance of a doctor. If necessary, according to the actual situation of the patient to choose incision and drainage of pus, tracheotomy, cricothyrotomy and other surgical treatment. Acute epiglottitis is an ear, nose and throat emergency and should be hospitalized to protect the patient’s life.