Because indapamide tablets and hydrochlorothiazide are both potassium-removing diuretic drugs, they are generally not recommended to be taken together. Indapamide tablets and hydrochlorothiazide actually belong to the same class of antihypertensive drugs, that is the diuretic class. Diuretics are generally not advocated in combinations of drugs to lower blood pressure. Hydrochlorothiazide belongs to the thiazide class of diuretics, and indapamide belongs to the sulfonamide class of diuretics, and the two antihypertensive drugs have similar antihypertensive mechanisms. In fact, not only these two antihypertensive drugs, any similar antihypertensive drugs should not be used together, which is the basic principle of hypertension medication. Indapamide tablets are contraindicated for patients with sulfonamide allergy, severe renal insufficiency, hepatic encephalopathy or severe hepatic insufficiency, hypokalemia and so on. And there may be diarrhea, headache, rash and other adverse reactions. Clinical contraindications to hydrochlorothiazide are unclear. Adverse reactions such as dry mouth, nausea, and extreme fatigue and weakness may occur. Therefore, patients who need to take potassium-excreting diuretic drugs are advised to do so under the guidance of a doctor and use them in strict accordance with medical advice, avoiding blind use of drugs.