Glomerular filtration rate of 75ml/min indicates that the glomerular filtration rate is reduced. If the glomerular filtration rate is reduced as a result of acute kidney injury, it can usually be restored to normal, while in the case of chronic renal insufficiency, it usually cannot be restored. 1. Acute kidney injury: For some acute kidney injuries, such as interstitial nephritis caused by drug allergy, insufficient renal perfusion due to ischemia and hypoxia, fluid retention in the kidney due to stones or urinary tract stenosis. According to the specific causes, remove the causes and with standardized treatment, most patients’ glomerular filtration rate can be restored to normal. 2. Chronic renal insufficiency: for chronic kidney disease, the glomerular filtration rate decrease, 75ml/min indicates that the glomerulus has problems with irreversible changes and usually cannot return to normal, but it can be controlled by active treatment of the primary pathology and effective management to control the progression, and the decrease of the glomerular filtration rate will also be slow. Decrease in glomerular filtration rate, the cause is more complex, need to regular hospitals, actively cooperate with doctors to standardize the treatment, can not blindly deal with their own and take medication, so as not to delay the treatment time.