Weakness of the ankle at rest should first be identified, and then targeted selection of general treatment, drug treatment, surgical treatment and other ways. The causes of ankle weakness at rest are over-exercise, lack of calcium, bone fracture, osteoporosis, etc. It is recommended to identify the causes of the disease before treatment and target treatment. 1. Excessive exercise: If the patient is engaged in strenuous sports, such as playing soccer, it is easy to cause the accumulation of lactic acid in the feet, and the ankle weakness and pain at rest, usually adequate rest and appropriate stretching can relieve this symptom. 2. Lack of calcium: the concentration of calcium ions can regulate muscle excitability, if the patient’s body lacks calcium, it is easy to cause ankle weakness, you can supplement vitamin D and calcium tablets. 3. Fracture: If the patient has ankle fracture, it needs to be reset and fixed in time, and the fracture displacement is obvious, it also needs to be reset by surgery, and the patient should cooperate with the doctor to carry out the rehabilitation training actively after the operation. 4. Osteoporosis: Osteoporosis can also cause ankle weakness in patients with severe osteoporosis, which can be supplemented with calcium tablets and vitamin D. Bisphosphonates can also be used to inhibit bone resorption and promote bone synthesis. There are many reasons for ankle weakness at rest, and it may be related to infections, lumbar disc herniation, etc. If the symptoms don’t get better after resting, it is recommended to go to the hospital in time to find out the cause of the disease and carry out targeted treatment. The use of drugs need to follow the doctor’s instructions.