Pepsinogen 1 does not reflect the severity of the disease and should not be relied upon to determine the severity of the disease, but rather should be analyzed in conjunction with other clinical manifestations and laboratory results. Pepsinogen 1 is an important indicator used to detect the ability of gastric acid cells to secrete gastric acid, and high or low values may be indicative of the disease, while the severity of the disease needs to be analyzed in conjunction with other data. When gastric acid secretion is insufficient, low pepsin 1 values will be manifested in the clinic, which is common in chronic atrophic gastritis and after partial gastrectomy; When gastric acid secretion is increased, the value of pepsinogen 1 will be high, which can be seen in patients with gastric ulcer and gastritis, and may also be related to some physiological factors. When the value of pepsin 1 is abnormal, it is necessary to consult the doctor in time and improve the gastroscopy and Helicobacter pylori test, so as to clarify the cause of the disease as soon as possible, and then symptomatic treatment.