Liver pain is seen in many kinds of diseases. For middle-aged and old-aged patients, if they have short-term weight loss and dark complexion accompanied by jaundice, the most common is malignant tumor of the liver, which is very serious in this case. Specifically, it is divided into primary liver cancer and secondary liver cancer. Primary liver cancer occurs mainly due to chronic viral hepatitis for many years, liver cirrhosis, and eventually transformed into liver cancer, and a part of middle-aged and old-aged male patients have malignant changes of alcoholic cirrhosis caused by long-term alcohol consumption. The patient’s laboratory test of alpha-fetoprotein will be obviously increased, and if there is no intrahepatic metastasis in the early diagnosis, the patient should choose surgical treatment in time. There is also a kind of metastatic hepatocellular carcinoma, mostly secondary to malignant tumors in the large intestine, in which case surgical treatment of the primary disease should be carried out, and interventional therapy can be chosen for the lesions in the liver.