The difference between H. pylori triple and quadruple is that quadruple therapy is the addition of a bismuth agent to triple therapy. H. pylori triple therapy is a proton pump inhibitor plus two antibiotics, and quadruple therapy is the addition of a bismuth agent to triple therapy. The current combination regimen advocated for H. pylori-associated gastritis is a quadruple regimen containing bismuth, i.e., a proton pump inhibitor plus two antibiotics and a bismuth, and the course of treatment is usually 10 to 14 days. The proton pump inhibitor can choose omeprazole, lansoprazole, rabeprazole, etc.; antibiotics can choose clarithromycin, amoxicillin, metronidazole, furazolidone, etc.; bismuth can choose bismuth potassium citrate, bismuth pectin, etc.. If diagnosed with Helicobacter pylori infection, early standardized treatment is recommended to reduce the adverse effects of the disease. Drugs need to be used under the guidance of a doctor.