EBV is a herpesvirus family lymphocyte virus genus, when EBV turns negative and then rise, need to continue the treatment, mainly including general treatment, drug treatment. 1. General treatment: When infected with EBV, you need to pay attention to rest and reduce the amount of activity. If you have fever, sore throat and other symptoms, you need to drink a lot of water to ensure that the amount of water is sufficient, and the diet should be light and nutritious. 2. Medication: If EBV infection is confirmed, oral antiviral drugs, such as acyclovir, ribavirin, and valacyclovir hydrochloride, should be taken under doctor’s supervision, and can be stopped when the virus turns negative. If the EB virus is negative and then rises, the need for medication must be under the guidance of a professional physician, and should not be taken without authorization, in order to avoid adverse consequences.