Sore buttocks may be caused by lumbar disc herniation, sciatica or ankylosing spondylitis, which can be treated with general treatment, physical therapy, medication or surgery according to the cause. 1. Lumbar disc herniation: Strict bed rest is generally recommended in the acute stage. If the pain is severe and normal activities are not possible, oral non-steroidal anti-inflammatory drugs can be taken for pain relief, such as aspirin and meloxicam. In more serious cases of lumbar disc herniation or prolapse, spinal endoscopic nucleus pulposus removal can be done. 2. Sciatica: After diagnosis, analgesics such as Celecoxib and Meloxicam should be used as soon as possible to control the condition. If necessary, oral neurotropic drugs, such as vitamin B12, methylcobalamin, etc., can be taken as prescribed by the doctor. In order to relieve the pain, combined with glucocorticoid drugs, such as Triamcinolone acetonide. 3. Ankylosing spondylitis: the lumbago caused by this disease can be oral meloxicam, diclofenac sodium pain, and then, if necessary, combined with anti-tumor necrosis factor a antagonist treatment, such as adalimumab, infliximab and so on. Different treatment measures should be taken for different causes of lumbago and buttock pain. Before treatment, it is necessary to go to the hospital for examination to understand the condition as well as the cause of the disease, and then targeted treatment, do not blindly use drugs.