Pregabalin and methylcobalamin can generally be taken together, Pregabalin is mostly used for the treatment of postherpetic neuralgia, methylcobalamin is mostly used for the treatment of peripheral neuropathy, and there is no contraindication to the use of the two. Pregabalin and methylcobalamin taken together, the two synergistic, can play the role of analgesic, nutritional nerve. Methylcobalamin is mostly used in the treatment of peripheral neuralgia and can normalize delayed synaptic transmission and neurotransmitter reduction. Pregabalin can have an analgesic effect on neuralgia caused by herpes zoster infection, and the two can be used together. Pregabalin is a gamma-aminobutyric acid (GABA) analog, which is similar in structure and action to gabapentin, and has antiepileptic, analgesic, and anxiolytic activity, and therefore can be used to treat postherpetic neuralgia. Methylcobalamin is endogenous vitamin B12, present in the blood and bone marrow, and it has a good affinity for neurons compared to vitamin B12, so it can be used in the treatment of peripheral neuropathy. Pregabalin is contraindicated in patients who are allergic to it, and methylcobalamin is contraindicated in patients who are allergic to it. If it is necessary to take both drugs, it is recommended to use them under the supervision of a physician.