There is no best treatment for melanoma, which needs to be treated by combining the patient’s condition with reasonable choices of surgical treatment, chemotherapy, radiation therapy, specific immunotherapy and non-specific immunotherapy, and targeted therapy. Melanoma, also known as malignant melanoma, is a malignant tumor originated from melanocytes with a relatively high degree of malignancy. 1. Surgery: Usually, after early melanoma is diagnosed and the lesion is relatively limited, surgery can be adopted to remove the lesion, and the commonly used surgical methods include intraoperative lymph node localization, selective lymph node dissection and so on, combined with chemotherapy when necessary. 2. Chemotherapy: if the melanoma has metastasized, chemotherapy or surgery combined with chemotherapy is needed, and local infusion chemotherapy can be used for malignant melanoma of extremities. Commonly used chemotherapy drugs include dacarbazine, temozolomide, paclitaxel and so on. 3. Radiation therapy: if there are visceral metastases or central nervous system metastases, radiation therapy can be adopted, which can effectively improve the symptoms of compression and improve the quality of life of patients. 4. Specific immunotherapy and non-specific immunotherapy: such as interferon, interleukin monoclonal antibody, antisense oligonucleotide technology, polyvalent cellular vaccine, peptide vaccine, etc., which can help to prolong the survival time of patients with advanced cutaneous melanoma. 5. Targeted therapy:Commonly used targeted drugs include Virofenib, Darafenib, etc., which can also treat melanoma. It is recommended that patients go to regular hospitals for consultation and choose appropriate treatment modalities under the guidance of doctors, so as to avoid delaying the condition. When using medication, strictly follow the doctor’s instructions to use medication, not blindly self-medication.