After five years of taking HIV medication, it is generally not prone to significant side effects, but some people may experience abnormalities in liver and kidney function, drowsiness, and skin rashes. HIV antiviral drugs need to be applied for a long time, and certain side effects will occur when applied for a long time. Whether it is necessary to change the drug or stop the drug should follow the doctor’s advice. Nucleoside antiviral drugs such as tenofovir, although the side effects are mild, but long-term use will affect the kidneys, but also affect the calcium and phosphorus metabolism, so you should monitor the renal function during the use of drugs. If the drug efavirenz and other non-nucleoside antitranscriptase inhibitor drugs, may be drowsy, insomnia and other neurological symptoms. Protease inhibitors such as lopinavir are prone to abnormal lipid metabolism and diarrhea in the early stages. When you have AIDS, you need to actively seek medical treatment, and drugs need to be rationally applied in accordance with medical advice.